Lrrc32^tm1Zhli
Targeted Allele Detail

Summary

• Symbol: Lrrc32^tm1Zhli
• Name: leucine rich repeat containing 32; targeted mutation 1, Zihai Li
• MGI ID: MGI:7314986
• Synonyms: GARP-FAST, GARP-FAST^-, GARP KO
• Gene: Lrrc32 Location: Chr7:98138515-98151038 bp, + strand Genetic Position: Chr7, 53.86 cM, cytoband E1-F2
• Alliance: Lrrc32^tm1Zhli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout)
• Mutation: Insertion
• Mutation details: A construct containing a loxP site, FRT site, neo-stop cassette, FRT site, tetO element, and loxP site was inserted upstream of the ATG site. Genomic PCR and flow cytometry analysis of platelets from P0 live pups confirmed the absence of expression in homozygous mutant neonates. (J:248781)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc32 Mutation: 30 strains or lines available

References

• Original: J:248781 Wu BX, et al., Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) beta3 and is essential for mouse palatogenesis. J Biol Chem. 2017 Nov 03;292(44):18091-18097
• All: 1 reference(s)