Katnal2^em1Zhlu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Katnal2^em1Zhlu
• Name: katanin p60 subunit A-like 2; endonuclease-mediated mutation 1, Zhongxian Lu
• MGI ID: MGI:7316544
• Synonyms: Katnal2^KO
• Gene: Katnal2 Location: Chr18:77064844-77135004 bp, - strand Genetic Position: Chr18, 52.02 cM, cytoband E3
• Alliance: Katnal2^em1Zhlu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using gRNAs 5'-ggatgcagctaaggctttgg-3' and 5'-gacttctggtgacatatctt-3' created a large fragment knockout. Western blot analysis confirmed the absence of protein expression in the testes of homozygous mutant males. (J:322392)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Katnal2 Mutation: 201 strains or lines available

References

• Original: J:322392 Wei X, et al., Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia. Clin Genet. 2021 Oct;100(4):376-385
• All: 1 reference(s)