Cfap65^em1Yqt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cfap65^em1Yqt
• Name: cilia and flagella associated protein 65; endonuclease-mediated mutation 1, Yue-Qiu Tan
• MGI ID: MGI:7316618
• Synonyms: Cfap65^-
• Gene: Cfap65 Location: Chr1:74941230-74974758 bp, - strand Genetic Position: Chr1, 38.54 cM
• Alliance: Cfap65^em1Yqt page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 4 through 11. Western blot analysis confirmed the absence of protein expression in the testes of homozygous mutant males. (J:325402)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfap65 Mutation: 91 strains or lines available

References

• Original: J:325402 Wang W, et al., CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis. Hum Mol Genet. 2021 Nov 16;30(23):2240-2254
• All: 1 reference(s)