Serac1^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Serac1^em1Bcgen
• Name: serine active site containing 1; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7316653
• Gene: Serac1 Location: Chr17:6092471-6130016 bp, - strand Genetic Position: Chr17, 3.67 cM
• Alliance: Serac1^em1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a approximate 6,898 bp deletion encompassing exons 3 to 7. Western blot analysis confirmed the absence of protein. (J:326672)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serac1 Mutation: 41 strains or lines available

References

• Original: J:326672 Fang H, et al., SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA. Sci Transl Med. 2022 Mar 2;14(634):eabl6992
• All: 1 reference(s)