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Mcpt8tm1.1(cre)Ics
Targeted Allele Detail
Summary
Symbol: Mcpt8tm1.1(cre)Ics
Name: mast cell protease 8; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:7327249
Synonyms: CT-M8, Mcpt8-Cre-tdTomato, Mcpt8CT, Mcpt8tm1Ics
Gene: Mcpt8  Location: Chr14:56319623-56322730 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Mcpt8tm1.1(cre)Ics page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:326806
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Mcpt8tm1.1(cre)Ics expression driven by 1 gene
 
Mutation detailsThe targeting construct inserted into exon 5 upstream of the stop codon an IRES, cre recombinase gene, T2A, Td-Tomato reporter gene, and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:326806)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mcpt8 (mouse)
Summary of all recombinase alleles driven by Mcpt8.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mcpt8 Mutation:  26 strains or lines available
References
Original:  J:326806 Tchen J, et al., CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development. Front Immunol. 2022;13:900532
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory