Mcpt8^{tm1.1(cre)Ics}
Targeted Allele Detail

Summary

• Symbol: Mcpt8^{tm1.1(cre)Ics}
• Name: mast cell protease 8; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7327249
• Synonyms: CT-M8, Mcpt8-Cre-tdTomato, Mcpt8^CT, Mcpt8^tm1Ics
• Gene: Mcpt8 Location: Chr14:56319623-56322730 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Mcpt8^{tm1.1(cre)Ics} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326806
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Mcpt8^{tm1.1(cre)Ics} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mcpt8 (MGI:1261780)

• Mutation details: The targeting construct inserted into exon 5 upstream of the stop codon an IRES, cre recombinase gene, T2A, Td-Tomato reporter gene, and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:326806)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mcpt8 (mouse) Summary of all recombinase alleles driven by Mcpt8. Comparative matrix view of recombinase activities Alliance mouse Mcpt8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcpt8 Mutation: 26 strains or lines available

References

• Original: J:326806 Tchen J, et al., CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development. Front Immunol. 2022;13:900532
• All: 2 reference(s)