Zdhhc19^em1Mngx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zdhhc19^em1Mngx
• Name: zinc finger, DHHC domain containing 19; endonuclease-mediated mutation 1, Mingxi Liu
• MGI ID: MGI:7327515
• Synonyms: Zdhhc19^-
• Gene: Zdhhc19 Location: Chr16:32315059-32326032 bp, + strand Genetic Position: Chr16, 22.76 cM
• Alliance: Zdhhc19^em1Mngx page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 10bp deletion in exon 5. Western blot analysis confirmed the absence of protein expression in homozygous mutant testes. (J:323394)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc19 Mutation: 100 strains or lines available

References

• Original: J:323394 Wu Y, et al., ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis. Biol Reprod. 2022 Mar 19;106(3):477-486
• All: 1 reference(s)