Cep250^em1Glvr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cep250^em1Glvr
• Name: centrosomal protein 250; endonuclease-mediated mutation 1, Gabriel Livera
• MGI ID: MGI:7327530
• Gene: Cep250 Location: Chr2:155798378-155840820 bp, + strand Genetic Position: Chr2, 77.26 cM
• Alliance: Cep250^em1Glvr page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting of exon 5 deleted 5bp and inserted a single bp (p.Met160Alafs*11) to produce a null allele. (J:324876)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cep250 Mutation: 98 strains or lines available

References

• Original: J:324876 Floriot S, et al., CEP250 is Required for Maintaining Centrosome Cohesion in the Germline and Fertility in Male Mice. Front Cell Dev Biol. 2021;9:754054
• All: 1 reference(s)