Myt1l^em1Mwer
Endonuclease-mediated Allele Detail

Summary

• Symbol: Myt1l^em1Mwer
• Name: myelin transcription factor 1-like; endonuclease-mediated mutation 1, Marius Wernig
• MGI ID: MGI:7328725
• Gene: Myt1l Location: Chr12:29578383-29973212 bp, + strand Genetic Position: Chr12, 11.86 cM
• Alliance: Myt1l^em1Mwer page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting exon 6 (the first coding exon) generated a 7 bp (ATCGCAC) deletion leading to a frameshift mutation at c.28 resulting in a predicted stop codon at c.231. (J:326588)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myt1l Mutation: 71 strains or lines available

References

• Original: J:326588 Wohr M, et al., Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice. Mol Autism. 2022 May 10;13(1):19
• All: 1 reference(s)