Clta^tm1.2Fmb
Targeted Allele Detail

Summary

• Symbol: Clta^tm1.2Fmb
• Name: clathrin light chain A; targeted mutation 1.2, Frances M Brodsky
• MGI ID: MGI:7328974
• Synonyms: CLCa KO, CLTA^ko
• Gene: Clta Location: Chr4:44004452-44032846 bp, + strand Genetic Position: Chr4, 23.09 cM, cytoband B1
• Alliance: Clta^tm1.2Fmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235591
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo flanked by FRT sites and a loxP site were inserted in intron 1 and a second loxP site was inserted into the 5 UTR. The selection cassette was removed via flp-mediated recombination. Cre-mediated recombination excised exon 1. (J:235591)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clta Mutation: 11 strains or lines available

References

• Original: J:235591 Wu S, et al., Clathrin light chains' role in selective endocytosis influences antibody isotype switching. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9816-21
• All: 3 reference(s)