Tubgcp4^tm1Rzh
Targeted Allele Detail

Summary

• Symbol: Tubgcp4^tm1Rzh
• Name: tubulin, gamma complex component 4; targeted mutation 1, Rongjia Zhou
• MGI ID: MGI:7329950
• Gene: Tubgcp4 Location: Chr2:121001135-121029251 bp, + strand Genetic Position: Chr2, 60.37 cM, cytoband F1
• Alliance: Tubgcp4^tm1Rzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282705
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 5.2-kb fragment containing a region of exon 2 to exon 6 was replaced with a 1.9-kb kanamycin-neomycin cassette. This generates exon 2-6 deletion and a frameshift after exon 1. (J:282705)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tubgcp4 Mutation: 36 strains or lines available

Notes

ES cells: SCR012 (129S6/SvEv)

References

• Original: J:282705 Li Z, et al., Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina. Cell Death Differ. 2019 Jun 17
• All: 2 reference(s)