Stx17^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stx17^em1(IMPC)J
• Name: syntaxin 17; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7330371
• Gene: Stx17 Location: Chr4:48124915-48186507 bp, + strand Genetic Position: Chr4, 26.07 cM
• Alliance: Stx17^em1(IMPC)J page
• IMPC: Stx17 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ATTACCAATTGTCTTCTACA and GCAACGACAAGGATTTACAA, which resulted in a 434 bp deletion beginning at Chromosome 4 position 48,158,693 bp and ending after 48,159,126 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001374906 (exon 4) and 211 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 63 and early truncation 14 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Stx17 Mutation: 22 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 1 reference(s)