Sar1b^em1Emle
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sar1b^em1Emle
• Name: secretion associated Ras related GTPase 1B; endonuclease-mediated mutation 1, Emile Levy
• MGI ID: MGI:7331421
• Synonyms: Sar1b^del
• Gene: Sar1b Location: Chr11:51654514-51682752 bp, + strand Genetic Position: Chr11, 31.41 cM
• Alliance: Sar1b^em1Emle page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 545 bp deletion removing exon 2 (GRCm38/mm10, Chr11:51,777,181-51,777,725 del). (J:319817)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sar1b Mutation: 21 strains or lines available

References

• Original: J:319817 Auclair N, et al., Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease. J Lipid Res. 2021 May 5;62:100085
• All: 2 reference(s)