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Rr253em2Kmm
Endonuclease-mediated Allele Detail
Summary
Symbol: Rr253em2Kmm
Name: regulatory region 253; endonuclease-mediated mutation 2, Kenneth M Murphy
MGI ID: MGI:7331607
Synonyms: Zeb2delta-165
Gene: Rr253  Location: unknown  Genetic Position: Chr2, Syntenic
Alliance: Rr253em2Kmm page
Mutation
origin
Strain of Origin:  STOCK Zeb2tm2.1Yhi/2YhiRbrc
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region)
Mutation:    Intergenic deletion
 
Mutation detailsThe Zeb2 enhancer, containing four E-boxes and located ~165 kb upstream, was targeted with sgRNAs (targeting GAGAGATCATCAAATG and GATAACGTTCTTGAAGCATA) using CRISPR/Cas9 technology, resulting in a 368 bp deletion. The allele was created in zygotes containing the Zeb2tm2.1Yhi allele. (J:316113)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr253 Mutation:  2 strains or lines available
References
Original:  J:316113 Huang X, et al., Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis. Immunity. 2021 Jul 13;54(7):1417-1432.e7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory