Mybpc2^tm1Ssad
Targeted Allele Detail

Summary

• Symbol: Mybpc2^tm1Ssad
• Name: myosin binding protein C, fast-type; targeted mutation 1, Sakthivel Sadayappan
• MGI ID: MGI:7331608
• Synonyms: C2^-
• Gene: Mybpc2 Location: Chr7:44151123-44174080 bp, - strand Genetic Position: Chr7, 28.83 cM
• Alliance: Mybpc2^tm1Ssad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2 to 22 were replaced with a loxP-flanked neomycin cassette. (J:309473)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mybpc2 Mutation: 54 strains or lines available

References

• Original: J:309473 Song T, et al., Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2003596118
• All: 2 reference(s)