Lgi3^tm1.2Mejr
Targeted Allele Detail

Summary

• Symbol: Lgi3^tm1.2Mejr
• Name: leucine-rich repeat LGI family, member 3; targeted mutation 1.2, Dies Meijer
• MGI ID: MGI:7331636
• Synonyms: Lgi3^delta1
• Gene: Lgi3 Location: Chr14:70768125-70775764 bp, + strand Genetic Position: Chr14, 36.32 cM
• Alliance: Lgi3^tm1.2Mejr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the first exon and an FRT-flanked neomycin cassette with a 3 loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin cassette. The first exon and its promoter were deleted via cre-mediated recombination. (J:327404)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgi3 Mutation: 33 strains or lines available

References

• Original: J:327404 Marafi D, et al., A reverse genetics and genomics approach to gene paralog function and disease: Myokymia and the juxtaparanode. Am J Hum Genet. 2022 Aug 6
• All: 2 reference(s)