Lpo^em1Zlu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lpo^em1Zlu
• Name: lactoperoxidase; endonuclease-mediated mutation 1, Zhe Lu
• MGI ID: MGI:7331667
• Synonyms: Lpo^del
• Gene: Lpo Location: Chr11:87697254-87716750 bp, - strand Genetic Position: Chr11, 52.22 cM, cytoband C
• Alliance: Lpo^em1Zlu page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted an approximate 12 kb fragment containing exons 4-11 (encoding 510 of the total 710 residues including all residues that form the catalytic center and the heme-biding site). (J:307289)

Expression

In Structures Affected by this Mutation:

31 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpo Mutation: 26 strains or lines available

References

• Original: J:307289 Yamakaze J, et al., Deletion of the lactoperoxidase gene causes multisystem inflammation and tumors in mice. Sci Rep. 2021 Jun 14;11(1):12429
• All: 1 reference(s)