Kmt2d^tm2.1Kaig
Targeted Allele Detail

Summary

• Symbol: Kmt2d^tm2.1Kaig
• Name: lysine (K)-specific methyltransferase 2D; targeted mutation 2.1, Kai Ge
• MGI ID: MGI:7333014
• Synonyms: Mll4SET^f
• Gene: Kmt2d Location: Chr15:98729550-98769085 bp, - strand
• Alliance: Kmt2d^tm2.1Kaig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273135
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 49 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 51. Flp-mediated recombination removed the neo cassette leaving exons 50 and 51, encoding the SET domain, floxed. (J:273135)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2d Mutation: 169 strains or lines available

References

• Original: J:273135 Jang Y, et al., H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. Nucleic Acids Res. 2019 Jan 25;47(2):607-620
• All: 5 reference(s)