Clk4^em1Yihc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clk4^em1Yihc
• Name: CDC like kinase 4; endonuclease-mediated mutation 1, Yi-Han Chen
• MGI ID: MGI:7333070
• Synonyms: Clk4^fl
• Gene: Clk4 Location: Chr11:51153941-51172597 bp, + strand Genetic Position: Chr11, 31.02 cM
• Alliance: Clk4^em1Yihc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 3 through 10. (J:327369)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clk4 Mutation: 37 strains or lines available

References

• Original: J:327369 Huang J, et al., CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation. Nat Commun. 2022 Jul 30;13(1):4433
• All: 1 reference(s)