Scrn1^em1Mkob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scrn1^em1Mkob
• Name: secernin 1; endonuclease-mediated mutation 1, Moira O'Bryan
• MGI ID: MGI:7334890
• Gene: Scrn1 Location: Chr6:54478158-54543474 bp, - strand Genetic Position: Chr6, 26.98 cM, cytoband B3
• Alliance: Scrn1^em1Mkob page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was deleted resulting in a premature stop codon in exon 4 and this was proven a null allele by the failure to detect the protein by immunohistochemistry and Western blot of testes. (J:307507)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scrn1 Mutation: 17 strains or lines available

References

• Original: J:307507 Houston BJ, et al., The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse. Dev Dyn. 2021 Jul;250(7):922-931
• All: 1 reference(s)