Mettl15^em1Pvs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl15^em1Pvs
• Name: methyltransferase like 15; endonuclease-mediated mutation 1, Petr V Sergiev
• MGI ID: MGI:7335017
• Gene: Mettl15 Location: Chr2:108922642-109111093 bp, - strand Genetic Position: Chr2, 56.52 cM
• Alliance: Mettl15^em1Pvs page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of the third (first coding) exon deleted two non-consecutive base pairs resulting in a frameshift and premature termination of translation. (J:325995)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl15 Mutation: 23 strains or lines available

References

• Original: J:325995 Averina OA, et al., Mitochondrial rRNA Methylation by Mettl15 Contributes to the Exercise and Learning Capability in Mice. Int J Mol Sci. 2022 May 27;23(11)
• All: 1 reference(s)