Dino^tm1.1Hyc
Targeted Allele Detail

Summary

• Symbol: Dino^tm1.1Hyc
• Name: damage induced long noncoding RNA; targeted mutation 1.1, Howard Chang
• MGI ID: MGI:7335151
• Synonyms: Dino^egfp
• Gene: Dino Location: Chr17:29312390-29313435 bp, - strand Genetic Position: Chr17, Syntenic
• Alliance: Dino^tm1.1Hyc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259337
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced most of the lncRNA with an EGFP reporter gene. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. The endogenous Trp53 response element within the Cdkn1a promoter remains intact. (J:259337)

Tumor Data

List all tumor models in MMHCdb carrying Dino^tm1.1Hyc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dino Mutation: 0 strains or lines available

References

• Original: J:259337 Schmitt AM, et al., An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet. 2016 Nov;48(11):1370-1376
• All: 3 reference(s)