Dino^tm2.1Hyc
Targeted Allele Detail

Summary

• Symbol: Dino^tm2.1Hyc
• Name: damage induced long noncoding RNA; targeted mutation 2.1, Howard Chang
• MGI ID: MGI:7335152
• Synonyms: Dino^lox
• Gene: Dino Location: Chr17:29312390-29313435 bp, - strand Genetic Position: Chr17, Syntenic
• Alliance: Dino^tm2.1Hyc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259337
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: The targeting construct introduced upstream of the lncRNA a loxP site and FRT site upstream of the lncRNA and an additional loxP site toward the 3 prime end of the lncRNA. The endogenous Trp53 response element within the Cdkn1a promoter remains intact. Expression was almost completely abrogated. (J:259337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dino Mutation: 0 strains or lines available

References

• Original: J:259337 Schmitt AM, et al., An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet. 2016 Nov;48(11):1370-1376
• All: 1 reference(s)