Tmem174^tm1Myz
Targeted Allele Detail

Summary

• Symbol: Tmem174^tm1Myz
• Name: transmembrane protein 174; targeted mutation 1, Makoto Miyazaki
• MGI ID: MGI:7336005
• Gene: Tmem174 Location: Chr13:98771486-98773918 bp, - strand Genetic Position: Chr13, 52.11 cM, cytoband D1
• Alliance: Tmem174^tm1Myz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328157
• Parent Cell Line: EC7.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129X1/SvJ)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin cassette replaced parts of exon 1 and 2 via homologous recombination. (J:328157)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem174 Mutation: 14 strains or lines available

References

• Original: J:328157 Miyazaki-Anzai S, et al., Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification. J Am Soc Nephrol. 2022 Aug;33(8):1477-1486
• All: 1 reference(s)