Tmem160^em1.1Bros
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem160^em1.1Bros
• Name: transmembrane protein 160; endonuclease-mediated mutation 1.1, Nils Brose
• MGI ID: MGI:7336126
• Synonyms: Tmem160^em1.1Schma
• Gene: Tmem160 Location: Chr7:16186867-16189415 bp, + strand Genetic Position: Chr7, 9.13 cM, cytoband A2
• Alliance: Tmem160^em1.1Bros page

Mutation origin

• Strain of Origin: C57BL/6JRj

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination introduced loxP sites surrounding exon 1. Cre mediated recombination removed exon 1. Immunohistology confirmed the absence of mRNA expression in dorsal root ganglion sensory neurons from homozygous mice. (J:328221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem160 Mutation: 6 strains or lines available

References

• Original: J:328221 Segelcke D, et al., Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice. Cell Rep. 2021 Dec 21;37(12):110152
• All: 1 reference(s)