BC004004^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: BC004004^em1Nju
• Name: cDNA sequence BC004004; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7336199
• Gene: BC004004 Location: Chr17:29487762-29521862 bp, + strand Genetic Position: Chr17, 15.17 cM, cytoband B1
• Alliance: BC004004^em1Nju page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exons 3 to 8. Western blot analysis confirmed absence of protein in lung tissues. (J:328326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any BC004004 Mutation: 46 strains or lines available

References

• Original: J:328326 Wang H, et al., Lack of bombesin receptor-activated protein attenuates bleomycin-induced pulmonary fibrosis in mice. Life Sci Alliance. 2022 Nov;5(11):e202201368
• All: 2 reference(s)