Leap2^em1Jmz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Leap2^em1Jmz
• Name: liver-expressed antimicrobial peptide 2; endonuclease-mediated mutation 1, Jeffrey M Zigman
• MGI ID: MGI:7336225
• Gene: Leap2 Location: Chr11:53313008-53313963 bp, - strand Genetic Position: Chr11, 31.94 cM
• Alliance: Leap2^em1Jmz page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 1616 bp from 655 bp upstream of the start codon to 271 bp downstream of the stop codon. (J:322589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Leap2 Mutation: 12 strains or lines available

References

• Original: J:322589 Shankar K, et al., LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Mol Metab. 2021 Aug 21;53:101327
• All: 1 reference(s)