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Leap2em1Jmz
Endonuclease-mediated Allele Detail
Summary
Symbol: Leap2em1Jmz
Name: liver-expressed antimicrobial peptide 2; endonuclease-mediated mutation 1, Jeffrey M Zigman
MGI ID: MGI:7336225
Gene: Leap2  Location: Chr11:53313008-53313963 bp, - strand  Genetic Position: Chr11, 31.94 cM
Alliance: Leap2em1Jmz page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR-targeting deleted 1616 bp from 655 bp upstream of the start codon to 271 bp downstream of the stop codon. (J:322589)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Leap2 Mutation:  12 strains or lines available
References
Original:  J:322589 Shankar K, et al., LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue. Mol Metab. 2021 Aug 21;53:101327
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory