Optn^tm1.1Htse
Targeted Allele Detail

Summary

• Symbol: Optn^tm1.1Htse
• Name: optineurin; targeted mutation 1.1, Henry Tseng
• MGI ID: MGI:7336815
• Synonyms: Optn^flox
• Gene: Optn Location: Chr2:5025453-5068862 bp, - strand Genetic Position: Chr2, 3.15 cM
• Alliance: Optn^tm1.1Htse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302744
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was introduced 5' of exon 1 and an FRT-neomycin-FRT-loxP cassette was placed 3' of exon 1. FLP-mediated recombination removed the neomycin cassette. (J:302744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Optn Mutation: 48 strains or lines available

References

• Original: J:302744 Wong SW, et al., Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease. Cell Death Differ. 2020 Jan;27(1):71-84
• All: 2 reference(s)