Cyfip2tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Cyfip2tm1c(EUCOMM)Wtsi |
Name: |
cytoplasmic FMR1 interacting protein 2; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7338923 |
Synonyms: |
Cyfip2flox |
Gene: |
Cyfip2 Location: Chr11:46084677-46203686 bp, - strand Genetic Position: Chr11, 27.61 cM, cytoband B1.2
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Alliance: |
Cyfip2tm1c(EUCOMM)Wtsi page
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IMPC: |
Cyfip2 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:326379
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 46170548 of Chromosome 11 upstream of exon 6 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 6 at position 46171429. Exon 6 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying the Cyfip2tm1a(EUCOMM)Wtsi allele.
(J:326379)
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Original: |
J:326379 Chaya T, et al., Deficiency of the neurodevelopmental disorder-associated gene Cyfip2 alters the retinal ganglion cell properties and visual acuity. Hum Mol Genet. 2022 Feb 21;31(4):535-547 |
All: |
3 reference(s) |
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