Clec9a^{tm4.1(cre/ERT2)Crs}
Targeted Allele Detail

Summary

• Symbol: Clec9a^{tm4.1(cre/ERT2)Crs}
• Name: C-type lectin domain family 9, member a; targeted mutation 4.1, Caetano Reis e Sousa
• MGI ID: MGI:7338965
• Synonyms: Clec9a^CreERT2
• Gene: Clec9a Location: Chr6:129385825-129401726 bp, + strand Genetic Position: Chr6, 63.3 cM
• Alliance: Clec9a^{tm4.1(cre/ERT2)Crs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327971
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Mutation: Insertion
• Clec9a^{tm4.1(cre/ERT2)Crs} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Clec9a (MGI:2444608)

• Mutation details: The allele was generated by conventional gene targeting (knock-in) adding P2A CreERT2 to the Clec9a gene. An FRT-flanked Neo cassette in the original constructs was removed by crossing to an FLPe expressing strain. (J:327971)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Clec9a (mouse) Summary of all recombinase alleles driven by Clec9a. Comparative matrix view of recombinase activities Alliance mouse Clec9a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clec9a Mutation: 29 strains or lines available

References

• Original: J:327971 Frederico B, et al., DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential. Dev Cell. 2022 Aug 22;57(16):1957-1975.e9
• All: 1 reference(s)