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Rr278em1Flc
Endonuclease-mediated Allele Detail
Summary
Symbol: Rr278em1Flc
Name: regulatory region 278; endonuclease-mediated mutation 1, Frank Conlon
MGI ID: MGI:7341598
Synonyms: Myh11deltai3
Gene: Rr278  Location: unknown  Genetic Position: Chr16, Syntenic
Alliance: Rr278em1Flc page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Modified regulatory region)
Mutation:    Intragenic deletion
 
Mutation detailsThis CHD4/GATA4/NKX2-5/TBX5-binding site-containing 414 bp cis-regulatory element (CRE) in Myh11 intron 3, suppressing Myh11 expression, was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in the deletion of the GATA-binding region all four transcription factors bind to. (J:324708)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr278 Mutation:  0 strains or lines available
References
Original:  J:324708 Robbe ZL, et al., CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart. Genes Dev. 2022 Apr 1;36(7-8):468-482
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory