Carm1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Carm1^{tm1c(EUCOMM)Hmgu}
• Name: coactivator-associated arginine methyltransferase 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7343758
• Gene: Carm1 Location: Chr9:21458163-21500763 bp, + strand Genetic Position: Chr9, Syntenic
• Alliance: Carm1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Carm1 gene page

Mutation origin

• Mutant Cell Lines: HEPD0719_6_E09, HEPD0719_6_E12, HEPD0719_6_F12
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 21485455 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 21487140. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:204812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Carm1 Mutation: 93 strains or lines available

References

• Original: J:204812 International Mouse Strain Resource, MGI download of germline transmission data for alleles from IMSR strain data. Database Download. 2014
• All: 1 reference(s)