Tg(Arc-tTA,-EGFP/Capzb*)10Mkyph
Transgene Detail
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Symbol: |
Tg(Arc-tTA,-EGFP/Capzb*)10Mkyph |
Name: |
transgene insertion 10, Maki Yamada |
MGI ID: |
MGI:7344056 |
Synonyms: |
AiCE-Tg, C57BL/6N-Tg(Arc-tTA/egfp/capzb*2)100Mkyph |
Transgene: |
Tg(Arc-tTA,-EGFP/Capzb*)10Mkyph Location: unknown
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Alliance: |
Tg(Arc-tTA,-EGFP/Capzb*)10Mkyph page
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Transgene Type: |
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Transgenic (Inserted expressed sequence, Reporter, Transactivator) |
Mutation: |
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Insertion
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Tg(Arc-tTA,-EGFP/Capzb*)10Mkyph expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Capzb (MGI:104652) |
beta2 splice variant |
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Mutation details: The transgenic construct contains a tetracycline-controlled transactivator (tTA), followed by a P2A self cleaving peptide, an EGFP/modified Capzb (capping actin protein of muscle Z-line subunit beta) fusion protein, and a polyA sequence under the control of the 7 kb mouse Arc (activity regulated cytoskeletal-associated protein) promoter. EGFP-CapZ retains native C-terminus region that caps F-actin and binds other major binding proteins. The beta2 splice variant is expressed primarily in the brain and less so in striated muscle, which has Capz in the Z disc.
(J:296392)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:296392 Kuboyama K, et al., Traceable stimulus-dependent rapid molecular changes in dendritic spines in the brain. Sci Rep. 2020 Sep 17;10(1):15266 |
All: |
2 reference(s) |
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