Rr293^tm1.1Mekk
Targeted Allele Detail

Summary

• Symbol: Rr293^tm1.1Mekk
• Name: regulatory region 293; targeted mutation 1.1, Marc Ekker
• MGI ID: MGI:7356588
• Synonyms: I12b^-
• Gene: Rr293 Location: Chr2:71366397-71366771 bp Genetic Position: Chr2, Syntenic
• Alliance: Rr293^tm1.1Mekk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312374
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The intergenic Dlx1/Dlx2 forebrain enhancer was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:312374)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr293 Mutation: 0 strains or lines available

References

• Original: J:312374 Fazel Darbandi S, et al., Increased Sociability in Mice Lacking Intergenic Dlx Enhancers. Front Neurosci. 2021;15:718948
• All: 1 reference(s)