Lrrc46^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc46^em1Cya
• Name: leucine rich repeat containing 46; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7366928
• Gene: Lrrc46 Location: Chr11:96925428-96932195 bp, - strand Genetic Position: Chr11, 60.65 cM, cytoband D
• Alliance: Lrrc46^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted 4075 bp encompassing exons 3-7. Immunoblotting of testis extracts confirmed absence of protein. (J:330199)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc46 Mutation: 20 strains or lines available

References

• Original: J:330199 Yin Y, et al., LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. Int J Mol Sci. 2022 Jul 31;23(15)
• All: 1 reference(s)