Kpna3^em2Maoka
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kpna3^em2Maoka
• Name: karyopherin subunit alpha 3; endonuclease-mediated mutation 2, Masahiro Oka
• MGI ID: MGI:7367175
• Synonyms: line 12B1
• Gene: Kpna3 Location: Chr14:61602660-61677323 bp, - strand Genetic Position: Chr14, 32.76 cM, cytoband C3
• Alliance: Kpna3^em2Maoka page

Mutation origin

• Strain of Origin: C57BL/6NCrSlc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 16 bp deletion. This is the 12B1 line. Western blot analysis confirmed the absence of protein. (J:303081)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpna3 Mutation: 40 strains or lines available

References

• Original: J:303081 Miyamoto Y, et al., Genetic loss of importin alpha4 causes abnormal sperm morphology and impacts on male fertility in mouse. FASEB J. 2020 Dec;34(12):16224-16242
• All: 2 reference(s)