Kpna4^tm1Maoka
Targeted Allele Detail

Summary

• Symbol: Kpna4^tm1Maoka
• Name: karyopherin subunit alpha 4; targeted mutation 1, Masahiro Oka
• MGI ID: MGI:7367178
• Gene: Kpna4 Location: Chr3:68979554-69034425 bp, - strand Genetic Position: Chr3, 32.18 cM, cytoband E2
• Alliance: Kpna4^tm1Maoka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303081
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette replaced exons 2 to 5. Western blot analysis confirmed the absence of protein in several tissues such as testis, brain, and lung. (J:303081)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kpna4 Mutation: 30 strains or lines available

References

• Original: J:303081 Miyamoto Y, et al., Genetic loss of importin alpha4 causes abnormal sperm morphology and impacts on male fertility in mouse. FASEB J. 2020 Dec;34(12):16224-16242
• All: 2 reference(s)