Rr304em1Drf
Endonuclease-mediated Allele Detail
|
Symbol: |
Rr304em1Drf |
Name: |
regulatory region 304; endonuclease-mediated mutation 1, David R FitzPatrick |
MGI ID: |
MGI:7367486 |
Synonyms: |
Tenm1CRE |
Gene: |
Rr304 Location: unknown Genetic Position: ChrX, Syntenic
|
Alliance: |
Rr304em1Drf page
|
|
Strain of Origin: |
Not Applicable
|
|
Allele Type: |
|
Endonuclease-mediated (Modified regulatory region) |
Mutation: |
|
Single point mutation
|
|
|
Mutation details: A G>A mutation was engineered in the Tenm1 cis-regulatory element (CRE) using an sgRNA (targeting AATATTATTAGCCACACATTTGG) and a ssODN template (TAAGATGGATTCATATTAGGGCTCAAATGCATTGATAGCATTCTACATATTTTTATCCATTTTTATTCCAAGCTACTTTTATCCAAATAGTTATAGACACAAGGTTATTGCAAATTGTATTTGTCTGCTGCCATAGTGCTTTCTATTTTAGAGGAGTAGAAGTAACTATCTCCTTAACAA) with CRISPR/Cas9 technology. The mutation mimics one found in some families with individuals presenting with X-linked intellectual disability (XLID).
(J:308813)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Rr304 Mutation: |
0 strains or lines available
|
|
Original: |
J:308813 Bengani H, et al., Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability. PLoS One. 2021;16(8):e0256181 |
All: |
1 reference(s) |
|