Agpat5^tm1Thor
Targeted Allele Detail

Summary

• Symbol: Agpat5^tm1Thor
• Name: 1-acylglycerol-3-phosphate O-acyltransferase 5; targeted mutation 1, Bernard Thorens
• MGI ID: MGI:7367581
• Synonyms: Agpat5^flox, Agpat5^tm1Geno
• Gene: Agpat5 Location: Chr8:18896295-18934429 bp, + strand Genetic Position: Chr8, 10.3 cM, cytoband A3
• Alliance: Agpat5^tm1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330249
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A lox2272 site was inserted upstream of exon 3 and a loxP site, tdTomato gene in opposite orientation, second lox2272, neomycin resistance gene, and second loxP site were inserted downstream of exon 3. (J:330249)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agpat5 Mutation: 46 strains or lines available

References

• Original: J:330249 Strembitska A, et al., Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion. Nat Commun. 2022 Sep 30;13(1):5761
• All: 1 reference(s)