Lrtm2^tm1.1Jaru
Targeted Allele Detail

Summary

• Symbol: Lrtm2^tm1.1Jaru
• Name: leucine-rich repeats and transmembrane domains 2; targeted mutation 1.1, Jun Aruga
• MGI ID: MGI:7378323
• Gene: Lrtm2 Location: Chr6:119292094-119307727 bp, - strand Genetic Position: Chr6, 56.73 cM
• Alliance: Lrtm2^tm1.1Jaru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325069
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the coding region with the phosphoglycerol kinase (PGK)-neo expression cassette flanked by a loxP sequence. Cre-mediated recombination removed the selection cassette. (J:325069)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrtm2 Mutation: 31 strains or lines available

References

• Original: J:325069 Ichise M, et al., Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics. Front Mol Neurosci. 2022;15:856315
• All: 1 reference(s)