Setd1a^em1Yzhg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Setd1a^em1Yzhg
• Name: SET domain containing 1A; endonuclease-mediated mutation 1, Yi Zhang
• MGI ID: MGI:7378548
• Gene: Setd1a Location: Chr7:127376561-127399294 bp, + strand Genetic Position: Chr7, 69.73 cM
• Alliance: Setd1a^em1Yzhg page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeted exon 15 and generated an 8 bp deletion that causes a frameshift and premature translation termination, mimicking the human loss-of-function mutations in patients with schizophrenia. (J:328716)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd1a Mutation: 57 strains or lines available

References

• Original: J:328716 Chen R, et al., Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis. Sci Adv. 2022 Mar 4;8(9):eabm1077
• All: 1 reference(s)