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Clec1atm1Yiw
Targeted Allele Detail
Summary
Symbol: Clec1atm1Yiw
Name: C-type lectin domain family 1, member a; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:7380613
Gene: Clec1a  Location: Chr6:129403647-129428963 bp, - strand  Genetic Position: Chr6, 63.32 cM
Alliance: Clec1atm1Yiw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:329240
Parent Cell Line:  EGR-101 (ES Cell)
Strain of Origin:  C57BL/6NSlc
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe genomic region containing the initiation codon in exon 1 was replaced with an EGFP and a loxP-flanked neomycin resistance gene under the phosphoglycerate kinase 1 promoter. Quantitative RT-PCR confirmed absence of transcript. (J:329240)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clec1a Mutation:  18 strains or lines available
References
Original:  J:329240 Makusheva Y, et al., The C-type lectin receptor Clec1A plays an important role in the development of experimental autoimmune encephalomyelitis by enhancing antigen presenting ability of dendritic cells and inducing inflammatory cytokine IL-17. Exp Anim. 2022 Aug 5;71(3):288-304
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory