Gcg^{tm1.1(cre/ERT2)Yasu}
Targeted Allele Detail

Summary

• Symbol: Gcg^{tm1.1(cre/ERT2)Yasu}
• Name: glucagon; targeted mutation 1.1, Yasuhiro Yamada
• MGI ID: MGI:7384334
• Synonyms: Gcg-CreERT2
• Gene: Gcg Location: Chr2:62304874-62313994 bp, - strand Genetic Position: Chr2, 35.85 cM
• Alliance: Gcg^{tm1.1(cre/ERT2)Yasu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330715
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gcg^{tm1.1(cre/ERT2)Yasu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gcg (MGI:95674)

• Mutation details: The targeting construct inserted an inducible cre/ERT2 fusion gene and rox-flanked selection cassette. Dre-mediated recombination removed the selection cassette. (J:330715)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gcg (mouse) Summary of all recombinase alleles driven by Gcg. Comparative matrix view of recombinase activities Alliance mouse Gcg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcg Mutation: 34 strains or lines available

References

• Original: J:330715 Hirano M, et al., MYCL-mediated reprogramming expands pancreatic insulin-producing cells. Nat Metab. 2022;4(2):254-268
• All: 1 reference(s)