Smc3^tm1.1Toshi
Targeted Allele Detail

Summary

• Symbol: Smc3^tm1.1Toshi
• Name: structural maintenance of chromosomes 3; targeted mutation 1.1, Toshihide Yamashita
• MGI ID: MGI:7384685
• Synonyms: Smc3 flox
• Gene: Smc3 Location: Chr19:53588827-53634262 bp, + strand Genetic Position: Chr19, 48.13 cM
• Alliance: Smc3^tm1.1Toshi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242006
• Parent Cell Line: BAC-BA1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a loxP and FRT flanked neo cassette was inserted downstream of exon 2 via homologous recombination. Flp-mediated recombination removed the neo cassette leaving exons 1 and 2 floxed. (J:242006)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smc3 Mutation: 47 strains or lines available

References

• Original: J:242006 Fujita Y, et al., Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J Exp Med. 2017 May 01;214(5):1431-1452
• All: 1 reference(s)