Cdc42ep1^tm1Yxz
Targeted Allele Detail

Summary

• Symbol: Cdc42ep1^tm1Yxz
• Name: CDC42 effector protein 1; targeted mutation 1, Yixian Zheng
• MGI ID: MGI:7384726
• Synonyms: Borg5^-
• Gene: Cdc42ep1 Location: Chr15:78726847-78735102 bp, + strand Genetic Position: Chr15, 37.7 cM
• Alliance: Cdc42ep1^tm1Yxz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310382
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence (most of exon 2 and exon 3) with part of the intron sequence was replaced by a neomycin-resistance gene. Immunofluorescence staining of embryonic hearts and Western blot analysis of primary endothelial cells confirmed absence of protein. (J:310382)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc42ep1 Mutation: 18 strains or lines available

References

• Original: J:310382 Liu Z, et al., Borg5 is required for angiogenesis by regulating persistent directional migration of the cardiac microvascular endothelial cells. Mol Biol Cell. 2014 Mar;25(6):841-51
• All: 1 reference(s)