Txnrd3^tm1Vgla
Targeted Allele Detail

Summary

• Symbol: Txnrd3^tm1Vgla
• Name: thioredoxin reductase 3; targeted mutation 1, Vadim N Gladyshev
• MGI ID: MGI:7384954
• Gene: Txnrd3 Location: Chr6:89620970-89652511 bp, + strand Genetic Position: Chr6, 40.01 cM
• Alliance: Txnrd3^tm1Vgla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330784
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The targeting construct replaced exon 3 with an IRES/beta-geo/polyadenylation cassette. (J:330784)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnrd3 Mutation: 27 strains or lines available

References

• Original: J:330784 Dou Q, et al., Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. J Biol Chem. 2022 Jun 23;298(8):102183
• All: 1 reference(s)