Sp140^em1Vnce
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sp140^em1Vnce
• Name: Sp140 nuclear body protein; endonuclease-mediated mutation 1, Russell Vance
• MGI ID: MGI:7386886
• Gene: Sp140 Location: Chr1:85528099-85572758 bp, + strand Genetic Position: Chr1, 43.6 cM
• Alliance: Sp140^em1Vnce page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 3 generated a null allele. (J:313901)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp140 Mutation: 23 strains or lines available

References

• Original: J:313901 Ji DX, et al., Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Elife. 2021 Jun 21;10:e67290
• All: 4 reference(s)