Tg(Vav1-Mpl)AAmol
Transgene Detail
|
Symbol: |
Tg(Vav1-Mpl)AAmol |
Name: |
transgene insertion A, Alison Moliterno |
MGI ID: |
MGI:7387059 |
Synonyms: |
MPLSV(A) |
Transgene: |
Tg(Vav1-Mpl)AAmol Location: unknown
|
Alliance: |
Tg(Vav1-Mpl)AAmol page
|
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Vav1-Mpl)AAmol expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Mpl (MGI:97076) |
Mpl splice variant |
|
|
|
Mutation details: The transgene is generated using full length Mpl splice variant (SV) cDNA cloned into the HS321/45-vav vector, which contains the mouse genomic Vav1 promoter sequence. The Mpl splice variant has 7 amino acids deleted from the N-terminal domain.This line carries an estimated 6 copies of the transgene and that the copy number is stable across multiple generations; however the transgene insertion site has not been confirmed.
(J:331302)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:331302 Spivak JL, Williams DM, Zhao ZJ, Rogers O, Duffield AS, Hankins WD, Moliterno AR, MPL SV, a Unique MPN MPL Splice Variant, Provokes a Fulminant Myeloid Leukemia in a JAK2 V617F Transgenic Mouse Model of Polycythemia Vera. Blood. 2015;126(23):484 |
All: |
1 reference(s) |
|