Ppp1r18^em1Mgin
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ppp1r18^em1Mgin
• Name: protein phosphatase 1, regulatory subunit 18; endonuclease-mediated mutation 1, Mark Ginsberg
• MGI ID: MGI:7388240
• Gene: Ppp1r18 Location: Chr17:36176485-36186488 bp, + strand Genetic Position: Chr17, 18.72 cM
• Alliance: Ppp1r18^em1Mgin page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting introduced seven stop codons downstream of the codon for the initiator methionine residue for the alpha form. The allele fails to express the alpha and beta isoforms. (J:331428)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r18 Mutation: 35 strains or lines available

References

• Original: J:331428 Lee HS, et al., Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs. J Exp Med. 2022 Aug 1;219(8):e20211637
• All: 1 reference(s)