Xpo7^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Xpo7^{tm1c(KOMP)Wtsi}
• Name: exportin 7; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7388252
• Synonyms: Xpo7-AB^fl
• Gene: Xpo7 Location: Chr14:70899566-71004075 bp, - strand Genetic Position: Chr14, 36.44 cM, cytoband D1
• Alliance: Xpo7^{tm1c(KOMP)Wtsi} page
• IMPC: Xpo7 gene page

Mutation origin

• Mutant Cell Line: EPD0357_3_G09
• Germline Transmission: Earliest citation of germline transmission: J:331429
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 70938916 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 70941266. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:331429)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xpo7 Mutation: 82 strains or lines available

References

• Original: J:331429 Modepalli S, et al., An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis. Exp Hematol. 2022 Aug 13
• All: 1 reference(s)